|
KMID : 0606319930090010027
|
|
Journal of Phamacetical Sciences Sookmyung Women s University
1993 Volume.9 No. 1 p.27 ~ p.44
|
|
|
Antitumor activity and nephrotoxicity of platinum complexes with carrier ligand as ethylenediamine
|
|
|
|
|
Abstract
|
|
|
Abstract:
@EN Several Pt(II) and Pt(IV) complexes of N,N'-bis(2-hydroxyethyl) ethylenediamine(2-HEen) and N,N'-bis(2-chloroethyl) ethylenediamine(2-CEen) as carrier ligand were prepared. Water-soluble Pt complexes were also prepared by modification of
leaving
groups.
The cytotoxicity of these compounds against leukemia P388 in vitro were tested. The Pt complexes containing 2-CEen showed higher antitumor activity than those containing 2-HEen.
Through the nephrotoxicity tests on the primary cultured proximal tubular cells of rabbit kidney and human kidney cells in vitro, Pt complexes with 2-CEen Showed higher than those with 2-HEen which were consistent with cytotoxicity but showed
very
low
nephrotoxicity compared with cisplatin. Also the valus of BUN and creatinine in serum of Pt complexes were reduced remarkable compared with cisplatin, therefore it can be concluded that new Pt complexes seems to have much lower nephrotoxicity
than
cisplatin.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|